Title : Heterozygous eNOS deficiency is associated with oxidative stress and endothelial dysfunction in diet-induced obesity.

Pub. Date : 2015 Dec

PMID : 26660551






2 Functional Relationships(s)
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1 Vascular superoxide levels as well as plasma levels of the pro-inflammatory cytokine interleukin-6 (IL-6) were selectively increased in HFD-fed eNOS(+/-) mice. Superoxides nitric oxide synthase 3, endothelial cell Mus musculus
2 The impairment produced by a HFD in eNOS(+/-) mice appears to be mediated by IL-6-induced increases in vascular superoxide. Superoxides nitric oxide synthase 3, endothelial cell Mus musculus