Pub. Date : 2015
PMID : 26656301
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Cisplatin Induces Overactivation of the Dormant Primordial Follicle through PTEN/AKT/FOXO3a Pathway which Leads to Loss of Ovarian Reserve in Mice. | Cisplatin | thymoma viral proto-oncogene 1 | Mus musculus |
| 2 | In this study, we investigated the role of PTEN/Akt/FOXO3 pathway in cisplatin-induced primordial follicle depletion. | Cisplatin | thymoma viral proto-oncogene 1 | Mus musculus |
| 3 | The activation of the PTEN/Akt/FOXO3 pathway cascade increased cytoplasmic translocation of FOXO3a in cisplatin-treated follicles, which in turn increased the pool size of growing follicles, and rapidly depleted the number of dormant follicles. | Cisplatin | thymoma viral proto-oncogene 1 | Mus musculus |
| 4 | This study is the first to show the involvement of the PTEN/Akt/FOXO3 pathway in premature ovarian failure after cisplatin treatment and the possibility of rescue through in vitro maturation. | Cisplatin | thymoma viral proto-oncogene 1 | Mus musculus |