PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 26656301-0 2015 Cisplatin Induces Overactivation of the Dormant Primordial Follicle through PTEN/AKT/FOXO3a Pathway which Leads to Loss of Ovarian Reserve in Mice. Cisplatin 0-9 thymoma viral proto-oncogene 1 Mus musculus 81-84 26656301-5 2015 In this study, we investigated the role of PTEN/Akt/FOXO3 pathway in cisplatin-induced primordial follicle depletion. Cisplatin 69-78 thymoma viral proto-oncogene 1 Mus musculus 48-51 26656301-9 2015 The activation of the PTEN/Akt/FOXO3 pathway cascade increased cytoplasmic translocation of FOXO3a in cisplatin-treated follicles, which in turn increased the pool size of growing follicles, and rapidly depleted the number of dormant follicles. Cisplatin 102-111 thymoma viral proto-oncogene 1 Mus musculus 27-30 26656301-12 2015 This study is the first to show the involvement of the PTEN/Akt/FOXO3 pathway in premature ovarian failure after cisplatin treatment and the possibility of rescue through in vitro maturation. Cisplatin 113-122 thymoma viral proto-oncogene 1 Mus musculus 60-63