Title : Dioscin alleviates alcoholic liver fibrosis by attenuating hepatic stellate cell activation via the TLR4/MyD88/NF-κB signaling pathway.

Pub. Date : 2015 Dec 10

PMID : 26655640






1 Functional Relationships(s)
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1 Our results showed that dioscin significantly attenuated hepatic stellate cells (HSCs) activation, improved collagen accumulation, and attenuated inflammation through down-regulating the levels of myeloid differentiation factor 88 (MyD88), nuclear factor kappaB (NF-kappaB), interleukin (IL)-1, IL-6 and tumour necrosis factor-alpha by decreasing Toll-like receptor (TLR)4 expression both in vivo and in vitro. dioscin interleukin 6 Homo sapiens