Title : Neuronal Stress Pathway Mediating a Histone Methyl/Phospho Switch Is Required for Herpes Simplex Virus Reactivation.

Pub. Date : 2015 Dec 9

PMID : 26651941






2 Functional Relationships(s)
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1 Surprisingly, JNK-mediated viral gene induction occurs independently of histone demethylases that remove repressive lysine modifications. Lysine mitogen-activated protein kinase 8 Homo sapiens
2 Rather, JNK signaling results in a histone methyl/phospho switch on HSV lytic promoters, a mechanism permitting gene expression in the presence of repressive lysine methylation. Lysine mitogen-activated protein kinase 8 Homo sapiens