Pub. Date : 2016 Feb
PMID : 26646023
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | RESULTS: Bupivacaine cardiotoxicity rapidly dephosphorylated Akt at S473 to 63 +- 5% of baseline and phosphorylated AMPK to 151 +- 19%. | Bupivacaine | AKT serine/threonine kinase 1 | Homo sapiens |
| 2 | Irreversible inhibition of Pi3k upstream of Akt exacerbated bupivacaine cardiotoxicity, whereas pretreating with a reversible inhibitor delayed the onset of toxicity. | Bupivacaine | AKT serine/threonine kinase 1 | Homo sapiens |
| 3 | CONCLUSION: Glucose handling by Akt and AMPK is integral to recovery from bupivacaine cardiotoxicity and modulation of these pathways by ILE contributes to lipid resuscitation. | Bupivacaine | AKT serine/threonine kinase 1 | Homo sapiens |