Title : BIM and mTOR expression levels predict outcome to erlotinib in EGFR-mutant non-small-cell lung cancer.

Pub. Date : 2015 Dec 7

PMID : 26639561






3 Functional Relationships(s)
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Sentence
Compound Name
Protein Name
Organism
1 BIM is a proapoptotic protein that initiates apoptosis triggered by EGFR tyrosine kinase inhibitors (TKI). bim epidermal growth factor receptor Homo sapiens
2 These data suggest that the combination of EGFR TKI with mTOR or PDE4 inhibitors could be adequate therapy for EGFR-mutant NSCLC patients with high pretreatment levels of BIM and mTOR. bim epidermal growth factor receptor Homo sapiens
3 These data suggest that the combination of EGFR TKI with mTOR or PDE4 inhibitors could be adequate therapy for EGFR-mutant NSCLC patients with high pretreatment levels of BIM and mTOR. bim epidermal growth factor receptor Homo sapiens