Title : In vitro and in vivo targeting of bladder carcinoma with metformin in combination with cisplatin.

Pub. Date : 2015 Aug

PMID : 26622608






1 Functional Relationships(s)
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1 Immunohistochemical analysis revealed that downregulation of the expression of specific proteins associated with AMPK promoted xenograft growth and angiogenesis, while western blotting revealed inhibition of the AKT/mTOR signaling pathway in xenografts treated with metformin in combination with cisplatin. Metformin AKT serine/threonine kinase 1 Homo sapiens