PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 26622608-13 2015 Immunohistochemical analysis revealed that downregulation of the expression of specific proteins associated with AMPK promoted xenograft growth and angiogenesis, while western blotting revealed inhibition of the AKT/mTOR signaling pathway in xenografts treated with metformin in combination with cisplatin. Metformin 266-275 AKT serine/threonine kinase 1 Homo sapiens 212-215