Title : Favorable effects of vildagliptin on metabolic and cognitive dysfunctions in streptozotocin-induced diabetic rats.

Pub. Date : 2015 Dec 15

PMID : 26607467






2 Functional Relationships(s)
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1 Moreover, vildagliptin significantly decreased serum levels of glucose and lipids (except high density lipoprotein) together with brain MDA, TNF-alpha, serum DPP-IV activities and NF-kappaB/p65 gene expression. Vildagliptin synaptotagmin 1 Rattus norvegicus
2 Results suggested that vildagliptin has a protective role in counteracting both metabolic abnormalities and memory deficits in diabetic rats, possibly via its anti-hyperglycemic, anti-inflammatory, antioxidant effects, together with reduction of brain NF-kappaB/p65 over expression. Vildagliptin synaptotagmin 1 Rattus norvegicus