Pub. Date : 2016 Mar
PMID : 26607136
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Both TFPI and FXa interact with several plasma proteins (e. g. prothrombin, FV/FVa, protein S) and non-proteinaceous compounds (e. g. phospholipids, heparin). | Heparin | tissue factor pathway inhibitor | Homo sapiens |
| 2 | Unfractionated heparin at concentrations (0.2-1 U/ml) enhanced FXa inhibition by TFPI ~8-fold, but impaired inhibition at concentrations > 1 U/ml. | Heparin | tissue factor pathway inhibitor | Homo sapiens |
| 3 | Direct FXa inhibition by TFPI is modulated by physiological concentrations prothrombin, FV, FVa, protein S, phospholipids and heparin indicating the importance of these modulators for the in vivo anticoagulant activity of TFPI. | Heparin | tissue factor pathway inhibitor | Homo sapiens |