Title : Inhibition of VCAM-1 expression on mouse vascular smooth muscle cells by lobastin via downregulation of p38, ERK 1/2 and NF-κB signaling pathways.

Pub. Date : 2016 Jan

PMID : 26597859






3 Functional Relationships(s)
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1 Lobastin also inhibited TNF-alpha-induced production of intracellular reactive oxygen species (ROS). Reactive Oxygen Species tumor necrosis factor Mus musculus
2 Lobastin also inhibited TNF-alpha-induced production of intracellular reactive oxygen species (ROS). Reactive Oxygen Species tumor necrosis factor Mus musculus
3 Our results indicate that lobastin downregulates the TNF-alpha-mediated induction of VCAM-1 in VSMC by inhibiting the p38, ERK 1/2 and NF-kappaB signaling pathways and intracellular ROS generation. Reactive Oxygen Species tumor necrosis factor Mus musculus