Title : Protective Role for Tissue Inhibitor of Metalloproteinase-4, a Novel Peroxisome Proliferator-Activated Receptor-γ Target Gene, in Smooth Muscle in Deoxycorticosterone Acetate-Salt Hypertension.

Pub. Date : 2016 Jan

PMID : 26597823






4 Functional Relationships(s)
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1 In this study, we examined the role of smooth muscle PPARgamma during salt-sensitive hypertension and investigated its transcriptional targets and functional effect. Salts peroxisome proliferator activated receptor gamma Mus musculus
2 Transgenic mice expressing dominant-negative PPARgamma (S-P467L) in smooth muscle cells were more prone to deoxycorticosterone acetate-salt-induced hypertension and mesenteric arterial dysfunction compared with nontransgenic controls. Salts peroxisome proliferator activated receptor gamma Mus musculus
3 Our findings highlight a protective mechanism induced by PPARgamma in deoxycorticosterone acetate-salt treatment, establishing a novel mechanistic link between PPARgamma and TIMP-4. Salts peroxisome proliferator activated receptor gamma Mus musculus
4 Our findings highlight a protective mechanism induced by PPARgamma in deoxycorticosterone acetate-salt treatment, establishing a novel mechanistic link between PPARgamma and TIMP-4. Salts peroxisome proliferator activated receptor gamma Mus musculus