Pub. Date : 2015 Dec 15
PMID : 26593430
5 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Farrerol can attenuate the aortic lesion in spontaneously hypertensive rats via the upregulation of eNOS and reduction of NAD(P)H oxidase activity. | farrerol | nitric oxide synthase 3 | Rattus norvegicus |
| 2 | Moreover, the levels of O2(-) along with NAD(P)H oxidase activity were reduced (P<0.05), while the activity of endothelial nitric oxide synthase (eNOS) was elevated (P<0.05) in aortic homogenates after the intervention of farrerol. | farrerol | nitric oxide synthase 3 | Rattus norvegicus |
| 3 | Moreover, the levels of O2(-) along with NAD(P)H oxidase activity were reduced (P<0.05), while the activity of endothelial nitric oxide synthase (eNOS) was elevated (P<0.05) in aortic homogenates after the intervention of farrerol. | farrerol | nitric oxide synthase 3 | Rattus norvegicus |
| 4 | Furthermore, farrerol upregulated the expression of eNOS in both of mRNA and protein levels, accompanied by the downregulated mRNA and protein expression of p22(phox) (P<0.05), an essential subunit for NADPH oxidase activity. | farrerol | nitric oxide synthase 3 | Rattus norvegicus |
| 5 | Our findings indicated that farrerol has a significant protective effect against the aortic lesion in SHR, which may be related to the enhanced eNOS activity and reduced NAD(P)H oxidase activity. | farrerol | nitric oxide synthase 3 | Rattus norvegicus |