Pub. Date : 2016 Jan
PMID : 26581637
8 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Free thiol groups in von Willebrand factor (VWF) are required for its full function under physiological flow conditions. | Sulfhydryl Compounds | von Willebrand factor | Homo sapiens |
| 2 | INTRODUCTION: von Willebrand factor (VWF) is rich in cysteine; next to important structural disulfide bonds, free thiol groups are present. | Sulfhydryl Compounds | von Willebrand factor | Homo sapiens |
| 3 | Free thiols on the surface of plasmatic VWF have been shown to play a role in VWF self-association and in platelet binding under pathologically high levels of shear stress. | Sulfhydryl Compounds | von Willebrand factor | Homo sapiens |
| 4 | Free thiols on the surface of plasmatic VWF have been shown to play a role in VWF self-association and in platelet binding under pathologically high levels of shear stress. | Sulfhydryl Compounds | von Willebrand factor | Homo sapiens |
| 5 | The present study explores the role of VWF free thiol groups under physiological levels of shear stress and in interactions with collagen and platelet-GPIbalpha receptor. | Sulfhydryl Compounds | von Willebrand factor | Homo sapiens |
| 6 | RESULTS: Blockade of free thiol groups significantly reduced VWF-mediated platelet recruitment to collagen under physiological flow conditions. | Sulfhydryl Compounds | von Willebrand factor | Homo sapiens |
| 7 | CONCLUSIONS: This study shows a significant contribution of free thiol groups in VWF to the mediation of platelet adhesion under physiological shear stress conditions. | Sulfhydryl Compounds | von Willebrand factor | Homo sapiens |
| 8 | The free thiol groups are shown to be involved in VWF binding to both collagen III and platelet GP1b receptor. | Sulfhydryl Compounds | von Willebrand factor | Homo sapiens |