Title : Docosahexaenoic acid inhibits inflammation via free fatty acid receptor FFA4, disruption of TAB2 interaction with TAK1/TAB1 and downregulation of ERK-dependent Egr-1 expression in EA.hy926 cells.

Pub. Date : 2016 Feb

PMID : 26577385






3 Functional Relationships(s)
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1 Docosahexaenoic acid inhibits inflammation via free fatty acid receptor FFA4, disruption of TAB2 interaction with TAK1/TAB1 and downregulation of ERK-dependent Egr-1 expression in EA.hy926 cells. Docosahexaenoic Acids mitogen-activated protein kinase 1 Homo sapiens
2 Pretreatment with DHA attenuated TNF-alpha-induced phosphorylation of ERK, expression of Egr-1 and ICAM-1 and HL-60 cell adhesion. Docosahexaenoic Acids mitogen-activated protein kinase 1 Homo sapiens
3 CONCLUSION: Our results suggest that the anti-inflammatory effect of DHA on the endothelium is at least partially linked to FFA4, disruption of TAB2 interaction with TAK1/TAB1 and downregulation of ERK-dependent Egr-1 and ICAM-1 expression, which leads to less HL-60 cell adhesion to TNF-alpha-stimulated EA.hy926 cells. Docosahexaenoic Acids mitogen-activated protein kinase 1 Homo sapiens