Pub. Date : 2016
PMID : 26569597
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | CYP2C9-based interaction was investigated for both 2-oxo-clopidogrel and glimepiride using HLM and the recombinant CYP2C9 system. | glimepiride | cytochrome P450 family 2 subfamily C member 9 | Homo sapiens |
| 2 | For the metabolism of 2-oxo-clopidogrel (the second step of bioactivation), glimepiride demonstrated a relatively strong inhibition against CYP2C9 activity (IC50 12.7 mumol/l). | glimepiride | cytochrome P450 family 2 subfamily C member 9 | Homo sapiens |
| 3 | In addition, 2-oxo-clopidogrel displayed a moderate inhibitory effect toward the CYP2C9-mediated metabolism of glimepiride. | glimepiride | cytochrome P450 family 2 subfamily C member 9 | Homo sapiens |