Pub. Date : 2015 Nov 13
PMID : 26566625
5 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | VEGF-activated miR-144 regulates autophagic survival of prostate cancer cells against Cisplatin. | Cisplatin | microRNA 144 | Homo sapiens |
| 2 | Moreover, microRNA (miR)-144 levels were significantly downregulated in cisplatin-treated PC cells, in a VEGF-dependent manner. | Cisplatin | microRNA 144 | Homo sapiens |
| 3 | In PC patients after cisplatin treatment, low miR-144 levels appeared to predict poor outcome of patients" survival. | Cisplatin | microRNA 144 | Homo sapiens |
| 4 | Together, these data suggest that cisplatin may induce VEGF to suppress miR-144 levels in PC cells, which subsequently upregulates Beclin-1 to increase autophagic cell survival against cisplatin-induced cell death. | Cisplatin | microRNA 144 | Homo sapiens |
| 5 | Upregulation of miR-144 or suppression of cell autophagy may improve the outcome of cisplatin therapy in PC. | Cisplatin | microRNA 144 | Homo sapiens |