Pub. Date : 2015 Nov 12
PMID : 26560363
7 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Regulation of iron homeostasis by the p53-ISCU pathway. | Iron | iron-sulfur cluster assembly enzyme | Homo sapiens |
| 2 | Here, we report that p53 regulates iron metabolism through the transcriptional regulation of ISCU (iron-sulfur cluster assembly enzyme), which encodes a scaffold protein that plays a critical role in Fe-S cluster biogenesis. | Iron | iron-sulfur cluster assembly enzyme | Homo sapiens |
| 3 | Here, we report that p53 regulates iron metabolism through the transcriptional regulation of ISCU (iron-sulfur cluster assembly enzyme), which encodes a scaffold protein that plays a critical role in Fe-S cluster biogenesis. | Iron | iron-sulfur cluster assembly enzyme | Homo sapiens |
| 4 | Here, we report that p53 regulates iron metabolism through the transcriptional regulation of ISCU (iron-sulfur cluster assembly enzyme), which encodes a scaffold protein that plays a critical role in Fe-S cluster biogenesis. | Iron | iron-sulfur cluster assembly enzyme | Homo sapiens |
| 5 | Knockdown of ISCU enhanced the binding of iron regulatory protein 1 (IRP1), a cytosolic Fe-S protein, to an iron-responsive element in the 5" UTR of ferritin heavy polypeptide 1 (FTH1) mRNA and subsequently reduced the translation of FTH1, a major iron storage protein. | Iron | iron-sulfur cluster assembly enzyme | Homo sapiens |
| 6 | Knockdown of ISCU enhanced the binding of iron regulatory protein 1 (IRP1), a cytosolic Fe-S protein, to an iron-responsive element in the 5" UTR of ferritin heavy polypeptide 1 (FTH1) mRNA and subsequently reduced the translation of FTH1, a major iron storage protein. | Iron | iron-sulfur cluster assembly enzyme | Homo sapiens |
| 7 | Our finding revealed a novel role of the p53-ISCU pathway in the maintenance of iron homeostasis in hepatocellular carcinogenesis. | Iron | iron-sulfur cluster assembly enzyme | Homo sapiens |