PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 26560363-0 2015 Regulation of iron homeostasis by the p53-ISCU pathway. Iron 14-18 iron-sulfur cluster assembly enzyme Homo sapiens 42-46 26560363-2 2015 Here, we report that p53 regulates iron metabolism through the transcriptional regulation of ISCU (iron-sulfur cluster assembly enzyme), which encodes a scaffold protein that plays a critical role in Fe-S cluster biogenesis. Iron 35-39 iron-sulfur cluster assembly enzyme Homo sapiens 93-97 26560363-2 2015 Here, we report that p53 regulates iron metabolism through the transcriptional regulation of ISCU (iron-sulfur cluster assembly enzyme), which encodes a scaffold protein that plays a critical role in Fe-S cluster biogenesis. Iron 99-103 iron-sulfur cluster assembly enzyme Homo sapiens 93-97 26560363-2 2015 Here, we report that p53 regulates iron metabolism through the transcriptional regulation of ISCU (iron-sulfur cluster assembly enzyme), which encodes a scaffold protein that plays a critical role in Fe-S cluster biogenesis. Iron 200-202 iron-sulfur cluster assembly enzyme Homo sapiens 93-97 26560363-4 2015 Knockdown of ISCU enhanced the binding of iron regulatory protein 1 (IRP1), a cytosolic Fe-S protein, to an iron-responsive element in the 5" UTR of ferritin heavy polypeptide 1 (FTH1) mRNA and subsequently reduced the translation of FTH1, a major iron storage protein. Iron 42-46 iron-sulfur cluster assembly enzyme Homo sapiens 13-17 26560363-4 2015 Knockdown of ISCU enhanced the binding of iron regulatory protein 1 (IRP1), a cytosolic Fe-S protein, to an iron-responsive element in the 5" UTR of ferritin heavy polypeptide 1 (FTH1) mRNA and subsequently reduced the translation of FTH1, a major iron storage protein. Iron 108-112 iron-sulfur cluster assembly enzyme Homo sapiens 13-17 26560363-9 2015 Our finding revealed a novel role of the p53-ISCU pathway in the maintenance of iron homeostasis in hepatocellular carcinogenesis. Iron 80-84 iron-sulfur cluster assembly enzyme Homo sapiens 45-49