Title : Anticipatory activation of the unfolded protein response by epidermal growth factor is required for immediate early gene expression and cell proliferation.

Pub. Date : 2016 Feb 15

PMID : 26551735






1 Functional Relationships(s)
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1 Within 2 min, EGF elicits EGFR dependent activation of phospholipase C gamma (PLCgamma), producing inositol triphosphate (IP3), which binds to IP3 receptor (IP3R), opening the endoplasmic reticulum IP3R Ca(2+) channels, resulting in increased intracellular Ca(2+). Inositol triphosphate epidermal growth factor receptor Homo sapiens