Title : Mechanism of Focal Adhesion Kinase Mechanosensing.

Pub. Date : 2015 Nov

PMID : 26544178






1 Functional Relationships(s)
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Protein Name
Organism
1 Tensile forces, propagating from the membrane through the PIP2 binding site of the FERM domain and from the cytoskeleton-anchored FAT domain, activate FAK by unlocking its central phosphorylation site (Tyr576/577) from the autoinhibitory FERM domain. Phosphatidylinositol 4,5-Diphosphate protein tyrosine kinase 2 Homo sapiens