Title : Combinatorial BTK and MALT1 inhibition augments killing of CD79 mutant diffuse large B cell lymphoma.

Pub. Date : 2015 Dec 8

PMID : 26540570






3 Functional Relationships(s)
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Compound Name
Protein Name
Organism
1 Inhibition of BTK by Ibrutinib has been shown to kill ABC DLBCL cells that carry activating mutations in the BCR adaptor CD79. ibrutinib Bruton tyrosine kinase Homo sapiens
2 However, mutations in BTK or in downstream components such as CARMA1/CARD11 can render lymphomas Ibrutinib resistant. ibrutinib Bruton tyrosine kinase Homo sapiens
3 Combined inhibition of BTK by Ibrutinib and MALT1 by S-Mepazine additively impaired MALT1 cleavage activity and expression of NF-kappaB pro-survival factors. ibrutinib Bruton tyrosine kinase Homo sapiens