Pub. Date : 2016 Jan
PMID : 26530054
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Nicotine enhances invasion and metastasis of human colorectal cancer cells through the nicotinic acetylcholine receptor downstream p38 MAPK signaling pathway. | Nicotine | mitogen-activated protein kinase 1 | Homo sapiens |
| 2 | Nicotine increased phosphorylation of p38, ERK, Akt and PI3K p85 but had no effect on phosphorylation of JNK, or NF-kappaB. | Nicotine | mitogen-activated protein kinase 1 | Homo sapiens |
| 3 | Nicotine increased phosphorylation of p38, ERK, Akt and PI3K p85 but had no effect on phosphorylation of JNK, or NF-kappaB. | Nicotine | mitogen-activated protein kinase 1 | Homo sapiens |
| 4 | We concluded that nicotine stimulates the invasion and metastasis of colon cancer cells in vitro via activation of the nAchRs and the p38 MAPK downstream signaling pathway. | Nicotine | mitogen-activated protein kinase 1 | Homo sapiens |