Pub. Date : 2015 Nov
PMID : 26519339
6 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Memantine ER/Donepezil: A Review in Alzheimer"s Disease. | Memantine | epiregulin | Homo sapiens |
| 2 | A once-daily, fixed-dose combination of memantine extended-release (ER)/donepezil 28/10 mg (Namzaric ) is available in the USA for patients with moderate to severe Alzheimer"s disease (AD) on stable memantine and donepezil therapy. | Memantine | epiregulin | Homo sapiens |
| 3 | In a 24-week, phase III trial in patients with moderate to severe AD, addition of memantine ER 28 mg once daily to stable cholinesterase inhibitor (ChEI) therapy was more effective than add-on placebo on measures of cognition, global clinical status, dementia behaviour and semantic processing ability, although between-group differences on a measure of daily function did not significantly differ. | Memantine | epiregulin | Homo sapiens |
| 4 | In subgroup analyses in donepezil-treated patients, add-on memantine ER was more effective than add-on placebo on measures of cognition, dementia behaviour and semantic processing, although there were no significant between-group differences on measures of global clinical status and daily function. | Memantine | epiregulin | Homo sapiens |
| 5 | Memantine ER plus ChEI combination therapy was generally well tolerated in the phase III trial, with diarrhoea, dizziness and influenza occurring at least twice as often with add-on memantine ER as add-on placebo in donepezil-treated patients. | Memantine | epiregulin | Homo sapiens |
| 6 | Thus, memantine ER plus donepezil combination therapy is an effective and well tolerated treatment option for patients with moderate to severe AD. | Memantine | epiregulin | Homo sapiens |