Pub. Date : 2015 Dec 1
PMID : 26517687
6 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | A novel chemical, STF-083010, reverses tamoxifen-related drug resistance in breast cancer by inhibiting IRE1/XBP1. | Tamoxifen | X-box binding protein 1 | Homo sapiens |
| 2 | In particular, human X-box binding protein-1(XBP1), a transcription factor which participates in UPR stress signaling, is reported to correlate with poor clinical responsiveness to tamoxifen. | Tamoxifen | X-box binding protein 1 | Homo sapiens |
| 3 | In particular, human X-box binding protein-1(XBP1), a transcription factor which participates in UPR stress signaling, is reported to correlate with poor clinical responsiveness to tamoxifen. | Tamoxifen | X-box binding protein 1 | Homo sapiens |
| 4 | In this study, we develop a tamoxifen-resistant MCF-7 cell line by treating the cell line with low concentration of tamoxifen, and we find that XBP1 is indeed up-regulated at both the mRNA and protein levels compared to normal MCF-7 cells. | Tamoxifen | X-box binding protein 1 | Homo sapiens |
| 5 | In this study, we develop a tamoxifen-resistant MCF-7 cell line by treating the cell line with low concentration of tamoxifen, and we find that XBP1 is indeed up-regulated at both the mRNA and protein levels compared to normal MCF-7 cells. | Tamoxifen | X-box binding protein 1 | Homo sapiens |
| 6 | STF-083010, a novel inhibitor which specifically blocks the XBP1 splicing, reestablishes tamoxifen sensitivity to resistant MCF-7 cells. | Tamoxifen | X-box binding protein 1 | Homo sapiens |