Title : Chemical probing of HER2-amplified cancer cells identifies TORC2 as a particularly effective secondary target for combination with lapatinib.

Pub. Date : 2015 Dec 1

PMID : 26516700






1 Functional Relationships(s)
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1 We conducted a comparative analysis of such secondary targets in combination with the HER2 inhibitor lapatinib and find that the inhibition of mTor affords the highest degree of synergy. Lapatinib mechanistic target of rapamycin kinase Homo sapiens