Title : Pulling habits out of rats: adenosine 2A receptor antagonism in dorsomedial striatum rescues meth-amphetamine-induced deficits in goal-directed action.

Pub. Date : 2017 Jan

PMID : 26515740






3 Functional Relationships(s)
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1 Reductions in c-Fos-related immunoreactivity were found in dorsomedial striatum (DMS) but not dorsolateral striatum after exposure to the METH context suggesting this effect reflected a loss specifically in goal-directed control in the METH context. Methamphetamine Fos proto-oncogene, AP-1 transcription factor subunit Rattus norvegicus
2 Reductions in c-Fos-related immunoreactivity were found in dorsomedial striatum (DMS) but not dorsolateral striatum after exposure to the METH context suggesting this effect reflected a loss specifically in goal-directed control in the METH context. Methamphetamine Fos proto-oncogene, AP-1 transcription factor subunit Rattus norvegicus
3 This reduction in c-Fos was localized to non-enkephalin-expressing neurons in the DMS, likely dopamine D1-expressing direct pathway neurons, suggesting a relative change in control by the D1-direct versus D2-indirect pathways originating in the DMS may have been induced by METH-context exposure. Methamphetamine Fos proto-oncogene, AP-1 transcription factor subunit Rattus norvegicus