Pub. Date : 2015 Dec 15
PMID : 26514304
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Chaetocin inhibits RANKL-induced osteoclast differentiation through reduction of Blimp1 in Raw264.7 cells. | chaetocin | tumor necrosis factor (ligand) superfamily, member 11 | Mus musculus |
| 2 | In this study, we examine the effect of chaetocin on RANKL-induced osteoclast differentiation and cell growth. | chaetocin | tumor necrosis factor (ligand) superfamily, member 11 | Mus musculus |
| 3 | KEY FINDINGS: Here we show that chaetocin dose-dependently reduced RANKL-induced osteoclast differentiation and cell growth via Blimp1 downregulation which results in the upregulation of osteoclast differentiation inhibitors and cell growth suppressors. | chaetocin | tumor necrosis factor (ligand) superfamily, member 11 | Mus musculus |
| 4 | SIGNIFICANCE: These results suggest that chaetocin suppresses RANKL-induced osteoclastogenesis and cell growth through blimp1 downregulation, followed by induction of anti-osteoclastogenic genes and cell growth suppressors, without inhibition of Suv39h1. | chaetocin | tumor necrosis factor (ligand) superfamily, member 11 | Mus musculus |