Title : NOX5-L can stimulate proliferation and apoptosis depending on its levels and cellular context, determining cancer cell susceptibility to cisplatin.

Pub. Date : 2015 Nov 17

PMID : 26513170






1 Functional Relationships(s)
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1 Notably, cisplatin treatment increased NOX5-L levels through CREB activation and enhanced NOX5-L activity through augmentation of Ca2+ release and c-Abl expression, ultimately triggering ROS-mediated cancer cell death-a distinct pathway absent in normal cells. Reactive Oxygen Species ABL proto-oncogene 1, non-receptor tyrosine kinase Homo sapiens