Title : A CuAAC-Hydrazone-CuAAC Trifunctional Scaffold for the Solid-Phase Synthesis of Trimodal Compounds: Possibilities and Limitations.

Pub. Date : 2015 Oct 23

PMID : 26512633






1 Functional Relationships(s)
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Compound Name
Protein Name
Organism
1 This scaffold holds two alkyne arms in a free and TIPS-protected form for consecutive CuAAC (copper(I)-catalyzed azide-alkyne cycloaddition), one Fmoc-protected hydrazide arm for reaction with aldehydes, and one carboxylic acid arm with CF2 groups for attachment to the resin and (19)F-NMR quantification. Azides ATPase H+ transporting accessory protein 1 Homo sapiens