Protein Name | ATPase H+ transporting accessory protein 1 |
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Organism | Homo sapiens |
Gene ID | 537 |
Gene Symbol | ATP6AP1 |
UniProt | Q15904 (VAS1_HUMAN), A0A384MQW4 (A0A384MQW4_HUMAN), A0A0C4DGX8 (A0A0C4DGX8_HUMAN) |
Relationships |
Total Number of functionally related compound(s) :
391
Total Number of Articles : 279 |
Description |
ATPase H+ transporting accessory protein 1 |
Gene Summary |
This gene encodes a component of a multisubunit enzyme that mediates acidification of eukaryotic intracellular organelles. Vacuolar ATPase (V-ATPase) is comprised of a cytosolic V1 (site of the ATP catalytic site) and a transmembrane V0 domain. V-ATPase dependent organelle acidification is necessary for such intracellular processes as protein sorting, zymogen activation, and receptor-mediated endocytosis. The encoded protein of this gene may assist in the V-ATPase-mediated acidification of neuroendocrine secretory granules. This protein may also play a role in early development. [provided by RefSeq, Aug 2013] |
synonyms |
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Properties | |