Protein Name ATPase H+ transporting accessory protein 1
Organism Homo sapiens
Gene ID 537
Gene Symbol

ATP6AP1

UniProt Q15904 (VAS1_HUMAN), A0A384MQW4 (A0A384MQW4_HUMAN), A0A0C4DGX8 (A0A0C4DGX8_HUMAN)
Relationships Total Number of functionally related compound(s) : 391
Total Number of Articles : 279
Description

ATPase H+ transporting accessory protein 1

Gene Summary

This gene encodes a component of a multisubunit enzyme that mediates acidification of eukaryotic intracellular organelles. Vacuolar ATPase (V-ATPase) is comprised of a cytosolic V1 (site of the ATP catalytic site) and a transmembrane V0 domain. V-ATPase dependent organelle acidification is necessary for such intracellular processes as protein sorting, zymogen activation, and receptor-mediated endocytosis. The encoded protein of this gene may assist in the V-ATPase-mediated acidification of neuroendocrine secretory granules. This protein may also play a role in early development. [provided by RefSeq, Aug 2013]

synonyms
  • V-type proton ATPase subunit S1
  • ATPase, H+ transporting, lysosomal (vacuolar proton pump), subunit 1
  • ATPase, H+ transporting, lysosomal accessory protein 1
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Properties