Title : Molecular mechanisms of gastrointestinal protection by quercetin against indomethacin-induced damage: role of NF-κB and Nrf2.

Pub. Date : 2016 Jan

PMID : 26507542






2 Functional Relationships(s)
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1 Quercetin prevented the decrease in nuclear translocation of Nrf2, a key regulator of the antioxidant response, and the increase in reactive oxygen species levels induced by INDO by inhibiting the enhancement of NADPH oxidase and xanthine oxidase activities as well as the reduction in superoxide dismutase and glutathione peroxidase activities in gastric and ileal tissues. Quercetin NFE2 like bZIP transcription factor 2 Homo sapiens
2 The protective effects of quercetin observed in the gastric and ileal mucosa of rats as well as in Caco-2 cells relied on the ability of this flavonol to prevent NF-kappaB activation and increase Nrf2 translocation. Quercetin NFE2 like bZIP transcription factor 2 Homo sapiens