Title : Early ionic events associated with phorbol ester induced differentiation and inhibition of cell growth in hematopoietic tumor cell lines.

Pub. Date : 1989 Jan-Feb

PMID : 2650613






2 Functional Relationships(s)
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1 Intracellular pH (pHi) was increased by TPA treatment; however, while the alkalinization of K-562 cells was dependent on the presence of extracellular Na+, the response of U-937 cells was unaffected by the removal of this cation. Tetradecanoylphorbol Acetate glucose-6-phosphate isomerase Homo sapiens
2 In each cell type the protein kinase C (PKC) inhibitor H-7 largely attenuated the TPA induced increase of pHi. Tetradecanoylphorbol Acetate glucose-6-phosphate isomerase Homo sapiens