Pub. Date : 2015 Oct 5
PMID : 26505347
6 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | AMP-activated protein kinase regulates autophagic protection against cisplatin-induced tissue injury in the kidney. | Cisplatin | protein kinase AMP-activated catalytic subunit alpha 2 | Homo sapiens |
| 2 | Interestingly, in the kidney, cisplatin treatment can activate AMP-activated protein kinase (AMPK), a signaling molecule that is also critical for p53-mediated inactivation of mammalian target of rapamycin (mTOR) pathways. | Cisplatin | protein kinase AMP-activated catalytic subunit alpha 2 | Homo sapiens |
| 3 | Interestingly, in the kidney, cisplatin treatment can activate AMP-activated protein kinase (AMPK), a signaling molecule that is also critical for p53-mediated inactivation of mammalian target of rapamycin (mTOR) pathways. | Cisplatin | protein kinase AMP-activated catalytic subunit alpha 2 | Homo sapiens |
| 4 | As a result, inhibition or knockdown of AMPK can lead to repressed autophagy in cisplatin-induced AKI, resulting in more DNA damage. | Cisplatin | protein kinase AMP-activated catalytic subunit alpha 2 | Homo sapiens |
| 5 | Activation of AMPK regulates autophagy during cisplatin-induced AKI. | Cisplatin | protein kinase AMP-activated catalytic subunit alpha 2 | Homo sapiens |
| 6 | Given the fact that p53 can regulate autophagy by inactivating mTOR via AMPK, our results suggest that the p53 pathway may also play a critical role in the pathogenesis of cisplatin-induced renal damage. | Cisplatin | protein kinase AMP-activated catalytic subunit alpha 2 | Homo sapiens |