Title : Discovery of 2-Acylaminothiophene-3-Carboxamides as Multitarget Inhibitors for BCR-ABL Kinase and Microtubules.

Pub. Date : 2015 Nov 23

PMID : 26501568






1 Functional Relationships(s)
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1 Among them, nine compounds, which share a common thiophene-based scaffold and adopt similar binding poses, were chosen for experimental testing and one of them was shown to have low micromolar inhibition activities against both WT and mutant ABL kinases. Thiophenes ABL proto-oncogene 1, non-receptor tyrosine kinase Homo sapiens