Pub. Date : 2015 Nov 27
PMID : 26498527
2 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Furthermore, a decrease in SIRT1 activity was found to play an important role in cisplatin-mediated small intestinal damage through nuclear factor (NF)-kappaB p65 activation, facilitated by its acetylation increase. | Cisplatin | nuclear factor kappa B subunit 1 | Homo sapiens |
| 2 | However, use of dunnione as a strong substrate for the NADH:quinone oxidoreductase 1 (NQO1) enzyme led to an increase in intracellular NAD(+) levels and prevented the cisplatin-induced small intestinal damage correlating with the modulation of PARP-1, SIRT1, and NF-kappaB. | Cisplatin | nuclear factor kappa B subunit 1 | Homo sapiens |