Pub. Date : 2015 Dec
PMID : 26496857
5 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Amplification by (-)-epigallocatechin gallate and chlorogenic acid of TNF-alpha-stimulated interleukin-6 synthesis in osteoblasts. | epigallocatechin gallate | interleukin 6 | Mus musculus |
| 2 | In the present study, the effects of EGCG and CGA on the TNF-alpha-stimulated interleukin-6 synthesis were investigated in MC3T3-E1 cells. | epigallocatechin gallate | interleukin 6 | Mus musculus |
| 3 | EGCG and CGA significantly enhanced TNF-alpha-stimulated interleukin-6 release. | epigallocatechin gallate | interleukin 6 | Mus musculus |
| 4 | In addition, the interleukin-6 mRNA expression levels induced by TNF-alpha were supported by EGCG, as well as CGA. | epigallocatechin gallate | interleukin 6 | Mus musculus |
| 5 | These results strongly suggest that EGCG and CGA enhance the TNF-alpha-stimulated interleukin-6 synthesis in osteoblasts, and that the amplifying effect of EGCG, but not CGA, is exerted via inhibiting p70 S6 kinase. | epigallocatechin gallate | interleukin 6 | Mus musculus |