Title : Molecular effects of Lapatinib in the treatment of HER2 overexpressing oesophago-gastric adenocarcinoma.

Pub. Date : 2015 Nov 3

PMID : 26484410






1 Functional Relationships(s)
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1 BACKGROUND: Lapatinib, a dual EGFR and HER2 inhibitor has shown disappointing results in clinical trials of metastatic oesophago-gastric adenocarcinomas (OGAs), and in vitro studies suggest that MET, IGFR, and HER3 confer resistance. Lapatinib insulin like growth factor 1 receptor Homo sapiens