Title : Resveratrol inhibits collagen-induced platelet stimulation through suppressing NADPH oxidase and oxidative inactivation of SH2 domain-containing protein tyrosine phosphatase-2.

Pub. Date : 2015 Dec

PMID : 26482867






1 Functional Relationships(s)
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1 Correlated with the inhibitory effects on NOX, resveratrol protected SH2 domain-containing protein tyrosine phosphatase-2 (SHP-2) from ROS-mediated inactivation and subsequently attenuated the specific tyrosine phosphorylation of key components (spleen tyrosine kinase, Vav1, Bruton"s tyrosine kinase, and phospholipase Cgamma2) for collagen receptor signaling cascades. Resveratrol vav guanine nucleotide exchange factor 1 Homo sapiens