Title : Cold-inducible RBM3 inhibits PERK phosphorylation through cooperation with NF90 to protect cells from endoplasmic reticulum stress.

Pub. Date : 2016 Feb

PMID : 26472337






2 Functional Relationships(s)
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1 Further, blocking RBM3 expression in human embryonic kidney HEK293 cells by specific small interfering RNAs increased phosphorylation of PERK and eIF2alpha, whereas overexpression of RBM3 prevented PERK-eIF2alpha-CHOP signaling during ER stress induced by thapsigargin or tunicamycin. Thapsigargin eukaryotic translation initiation factor 2 alpha kinase 3 Homo sapiens
2 Further, blocking RBM3 expression in human embryonic kidney HEK293 cells by specific small interfering RNAs increased phosphorylation of PERK and eIF2alpha, whereas overexpression of RBM3 prevented PERK-eIF2alpha-CHOP signaling during ER stress induced by thapsigargin or tunicamycin. Thapsigargin eukaryotic translation initiation factor 2 alpha kinase 3 Homo sapiens