Pub. Date : 2016 Jan 15
PMID : 26472220
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Nicotine reduces the levels of surfactant proteins A and D via Wnt/beta-catenin and PKC signaling in human airway epithelial cells. | Nicotine | surfactant protein A1 | Homo sapiens |
| 2 | We recently showed that in vitro nicotine exposure induces Wnt3a/beta-catenin activation, which is a pathway that has also been implicated in altering levels of SP-A and SP-D. | Nicotine | surfactant protein A1 | Homo sapiens |
| 3 | The main aim of this study was to investigate whether human bronchial epithelial cells reduce levels of SP-A and SP-D in vitro following nicotine stimulation via the Wnt3a/beta-catenin and PKC signaling pathway. | Nicotine | surfactant protein A1 | Homo sapiens |
| 4 | We showed that nicotine activated the Wnt3a/beta-catenin and PKC signaling pathway, and this activation was accompanied by a decrease in SP-A and SP-D expression. | Nicotine | surfactant protein A1 | Homo sapiens |