Protein Name surfactant protein A1
Organism Homo sapiens
Gene ID 653509
Gene Symbol

SFTPA1

UniProt Q8IWL2 (SFTA1_HUMAN), A0A024QZP2 (A0A024QZP2_HUMAN), B4DNP6 (B4DNP6_HUMAN)
Relationships Total Number of functionally related compound(s) : 477
Total Number of Articles : 572
Description

surfactant protein A1

Gene Summary

This gene encodes a lung surfactant protein that is a member of a subfamily of C-type lectins called collectins. The encoded protein binds specific carbohydrate moieties found on lipids and on the surface of microorganisms. This protein plays an essential role in surfactant homeostasis and in the defense against respiratory pathogens. Mutations in this gene are associated with idiopathic pulmonary fibrosis. Alternate splicing results in multiple transcript variants. [provided by RefSeq, May 2010]

synonyms
  • pulmonary surfactant-associated protein A1
  • 35 kDa pulmonary surfactant-associated protein
  • alveolar proteinosis protein
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Properties