Title : Nicotine reduces the levels of surfactant proteins A and D via Wnt/β-catenin and PKC signaling in human airway epithelial cells.

Pub. Date : 2016 Jan 15

PMID : 26472220






3 Functional Relationships(s)
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1 Nicotine reduces the levels of surfactant proteins A and D via Wnt/beta-catenin and PKC signaling in human airway epithelial cells. Nicotine catenin beta 1 Homo sapiens
2 We recently showed that in vitro nicotine exposure induces Wnt3a/beta-catenin activation, which is a pathway that has also been implicated in altering levels of SP-A and SP-D. Nicotine catenin beta 1 Homo sapiens
3 We showed that nicotine activated the Wnt3a/beta-catenin and PKC signaling pathway, and this activation was accompanied by a decrease in SP-A and SP-D expression. Nicotine catenin beta 1 Homo sapiens