Title : Biochemical and structural characterization of HDAC8 mutants associated with Cornelia de Lange syndrome spectrum disorders.

Pub. Date : 2015 Oct 27

PMID : 26463496






1 Functional Relationships(s)
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1 Molecular dynamics simulations of H180R and G304R HDAC8 mutants suggest that the bulky arginine side chain of each mutant protrudes into the substrate binding site and also causes active site residue Y306 to fluctuate away from the position required for substrate activation and catalysis. Arginine histone deacetylase 8 Homo sapiens