Pub. Date : 2015 Nov 15
PMID : 26459208
2 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Pim-2, among the three Pim isoforms, plays a critical role in multiple myeloma yet inhibition of Pim-2 is challenging due to its high affinity for ATP. | Adenosine Triphosphate | Pim-1 proto-oncogene, serine/threonine kinase | Homo sapiens |
| 2 | A co-crystal structure of a screening hit 1 bound to Pim-1 kinase revealed the key binding interactions of its indazole core within the ATP binding site. | Adenosine Triphosphate | Pim-1 proto-oncogene, serine/threonine kinase | Homo sapiens |