Pub. Date : 2016 Jan
PMID : 26446867
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Possible role of P-glycoprotein in the neuroprotective mechanism of berberine in intracerebroventricular streptozotocin-induced cognitive dysfunction. | Berberine | ATP-binding cassette, subfamily B (MDR/TAP), member 1B | Rattus norvegicus |
| 2 | However, the neurological mechanism of berberine remains untapped in the light of its P-glycoprotein (P-gp)-mediated gut efflux properties responsible for reduced bioavailability. | Berberine | ATP-binding cassette, subfamily B (MDR/TAP), member 1B | Rattus norvegicus |
| 3 | However, the neurological mechanism of berberine remains untapped in the light of its P-glycoprotein (P-gp)-mediated gut efflux properties responsible for reduced bioavailability. | Berberine | ATP-binding cassette, subfamily B (MDR/TAP), member 1B | Rattus norvegicus |
| 4 | CONCLUSION: The augmentative outcome of verapamil on the neuroprotective effect of berberine can be speculated due to the inhibition of P-gp efflux mechanism and the prevention of calcium homeostasis alteration. | Berberine | ATP-binding cassette, subfamily B (MDR/TAP), member 1B | Rattus norvegicus |