Title : Crizotinib-induced antitumour activity in human alveolar rhabdomyosarcoma cells is not solely dependent on ALK and MET inhibition.

Pub. Date : 2015 Oct 6

PMID : 26445453






1 Functional Relationships(s)
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1 RESULTS: In vitro treatment with crizotinib inhibited ALK and MET proteins, as well as Insulin-like Growth Factor 1 Receptor (IGF1R), with a concomitant robust dephosphorylation of AKT and ERK, two downstream kinases involved in RMS cell proliferation and survival. Crizotinib mitogen-activated protein kinase 1 Homo sapiens