Pub. Date : 2015 Nov 3
PMID : 26440150
2 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
1 | Fendiline inhibits proliferation and invasion of pancreatic cancer cells by interfering with ADAM10 activation and beta-catenin signaling. | Fendiline | catenin beta 1 | Homo sapiens |
2 | Furthermore, the expression of beta-catenin target genes, cyclinD1, c-Myc and CD44, were significantly decreased, suggesting that fendiline might prevent cell proliferation and migration by inhibiting ADAM10 function, cadherin proteolysis and stabilization of cadherin-catenin interaction at the plasma membrane. | Fendiline | catenin beta 1 | Homo sapiens |