Title : Population pharmacokinetics and pharmacodynamics of busulfan with GSTA1 polymorphisms in patients undergoing allogeneic hematopoietic stem cell transplantation.

Pub. Date : 2015

PMID : 26419450






3 Functional Relationships(s)
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1 Population pharmacokinetics and pharmacodynamics of busulfan with GSTA1 polymorphisms in patients undergoing allogeneic hematopoietic stem cell transplantation. Busulfan glutathione S-transferase alpha 1 Homo sapiens
2 AIM: A population pharmacokinetic (PPK) analysis was conducted to describe the influence of GSTA1 polymorphisms on intravenous busulfan in adults undergoing allogeneic hematopoietic stem cell transplantation. Busulfan glutathione S-transferase alpha 1 Homo sapiens
3 CONCLUSION: To our knowledge, this is the first PPK study to suggest that GSTA1 polymorphisms in adults are associated with busulfan PK. Busulfan glutathione S-transferase alpha 1 Homo sapiens